Dozens of putative substrates that control glycogen metabolism, protein synthesis and cell apoptosis were characterized to be phosphorylated by GSK3β.39–42 Aberrant GSK3β expression and activity elicit the development of numerous diseases such as diabetes, cancer and AD.43 Therefore, GSK3β is considered an important target in drug discovery research and many inhibitory candidates are under characterization.44–46. The gene discussed is GSK3B; the disease is Alzheimer disease.