Compared to the control group, rTIMP3 significantly up-regulated signaling pathways of chemokine, cytokine-cytokine receptor interaction, MAPK, NF-κB, PI3K-Akt, TNF, and Toll-like receptor, while down-regulated pathways of adrenergic signaling in cardiomyocytes, cardiac muscle contraction, DCM, HCM, and oxidative phosphorylation (Supplementary Table S2). Here, AKT1 is linked to familial dilated cardiomyopathy.