19 pathways were significantly modified, including adrenergic signaling in cardiomyocytes, cAMP signaling pathway, cardiac muscle contraction, cytokine-cytokine receptor interaction, dilated cardiomyopathy (DCM), extracellular matrix (ECM)-receptor interaction, focal adhesion, hypertrophic cardiomyopathy (HCM), mitogen activated protein kinase (MAPK) signaling pathway, nuclear factor-κB (NF-κB) signaling pathway, and PI3K-Akt signaling pathway (Figure 1B). Here, WNK2 is linked to familial dilated cardiomyopathy.