B2M and neoplasm: In concordance with our previous observations, high B2M expression in the tumor compartment showed significant association with increased PFS [HR, 0.41; 95% CI, 0.19–0.93; P = 0.034] and had a similar trend for OS [HR, 0.44; 95% CI, 0.19–1.0; P = 0.074] (Fig. 3C and D) and maintained the same effect in multivariate analysis (Supplementary Fig. S4B and S4C).