NFE2L2 and tauopathy: Fumarates are thiol-reactive electrophilic agents that directly activate the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway to mitigate cellular oxidative stress (Akino et al., 2019); in addition, the latter is indirectly activated by the survival kinase AKT, affording neuroprotection against tauopathy in a mouse model (Cuadrado et al., 2018).