The inhibition of the disruptor of telomeric silencing 1-like expression reduces methylation modification of histone H3 on spleen tyrosine kinase promoter, which can inhibit the TGF-β1/smad3 axis and prevent myocardial fibrosis and CFs proliferation (Li et al., 2022a). Here, TGFB1 is linked to Myocardial fibrosis.