For example, B cells infiltrate into damaged myocardium within 1–7 days (Adamo et al., 2020), and B cells deficiency downregulates cytokines (e.g., TNF-α, IL-1β, IL-6, and TGF-1β) and collagen synthesis to alleviate fibrosis after MI (Mo et al., 2021). Here, IL1B is linked to myocardial infarction.