According to the features and location of ECM protein deposition, there are usually two species of post-MI fibrosis: reparative and reactive fibrosis, with the former directly replacing necrotic cardiac tissue after MI and the latter being the pathological consequence of over-activated CFs and including perivascular and interstitial fibrosis (de Boer et al., 2019). The gene discussed is PROS1; the disease is myocardial infarction.