There are also other growth factors involved in cardiac fibrosis, such as neuregulin-1, a paracrine growth factor secreted by cardiac endothelial cells, modulates hypertrophic and fibrotic processes during early cardiac remodeling via the neuregulin-1/erythroblastic leukemia viral oncogene homolog (ERBB) four axis (Dugaucquier et al., 2020). This evidence concerns the gene NRG1 and fibrosis.