Further, zinc finger protein ZBTB20 protects the heart by inhibiting the JNK pathway (Li et al., 2020a; Li et al., 2020b), while melatonin improves myocardial fibrosis in the infarct border zone and apoptosis via the JNK/p53 pathway after MI in a diabetic mouse model (Lu et al., 2020). The gene discussed is TP53; the disease is myocardial infarction.