Our findings showed, for the first time, that PPE ameliorates the impact of diabetes on the myocardium and revealed the likely mechanisms of its favorable effects, which are downregulation of lncRNA-MALAT1, with subsequent downregulation of the pyroptosis-related genes (NLRP3 and caspase-1), and reduction of IL-1β. The gene discussed is CASP1; the disease is diabetes mellitus.