The Nrf2-dependent antioxidant response is a well-known protective mechanism against cardiovascular diseases and insults, including myocardial infarction 49, aortic stenosis 50, streptozotocin-induced cardiac toxicity 51, myocardial ischemia reperfusion injury 52, diabetic cardiomyopathy 53, and atherosclerosis 54. The gene discussed is NFE2L2; the disease is aortic stenosis.