In a mouse model of S. aureus-induced septic arthritis, treatment with the synthetic retinoid derivative adapalene inhibits inflammation and promotes anti-inflammatory M2 polarization in macrophages by repressing AURKA-mediated WNT signaling and promoting Hippo signaling through activatory phosphorylation of STK3, STK4, and LATS1 46. This evidence concerns the gene STK4 and bacterial arthritis.