Moreover, transfection of ACKR2 siRNA prevented CXCL14-activated PLCβ3, PKCα, and c-Src phosphorylation (Figure 4L), indicating that CXCL14 promoted lung cancer cell migration and EMT through activation of ACKR2/PLCβ3/PKCα/c-Src signaling pathway. Here, PLCB3 is linked to lung cancer.