The Cancer Genome Atlas (TCGA) provided the landscape in tumorigenic signaling pathways, and the research group led by Schultz investigated the mechanisms and patterns of somatic alterations in 10 canonical pathways 11: cell cycle, Hippo, Myc, Notch, Nrf2, PI3K/Akt, RTK-RAS, TGFβ, p53, and β-catenin/Wnt. This evidence concerns the gene MYC and cancer.