Among them, the actions of 6 tumor-suppressing proteins, ENO1, Ubiquitin C (UBC), Moesin (MSN), heat shock protein 90ab1 (HSP90ab1, aka HSP90β), Calreticulin (CALR), and Histone H4 (H4), have been documented with a proposed mechanism (Figure 1) 12-14. The gene discussed is ENO1; the disease is neoplasm.