Further assays revealed that E-cad was increased whereas expressions of Vim, Snail, and p-JNK were decreased significantly in anti-Ly6G-treated group with relative to the IgG-treated group (Figure 6D, 6E, 6F, s5G), suggesting that neutrophil depletion prevents gastric cancer tumorigenesis through inhibiting EMT. The gene discussed is MAPK8; the disease is gastric cancer.