SLC2A4 and type 2 diabetes mellitus: Therefore, we established a firefly luciferase reporter screening system driven by the GLUT4 gene promoter to screen for potential compounds promoting GLUT4 expression and further investigated the effects of the compound candidates on IR or T2DM, thus exploring the possibility of obtaining potential anti-IR or anti-T2DM lead compounds using this screening system with GLUT4 as the target.