However, prophylactic and therapeutic uses of TG both significantly increased GLUT4 levels in the muscle tissues of T2DM mice in a dose-dependent manner and the GLUT4 levels in the muscles of TG-treated T2DM mice were even higher than those of ND mice (Fig. 3C and D), indicating that TG exhibits strong stimulatory effects on GLUT4 expression in muscle in vivo. Here, SLC2A4 is linked to type 2 diabetes mellitus.