Additionally, Carotti et al. also found that FMR1 was upregulated in intrahepatic cholangiocarcinoma, bound to Cortactin (a marker of mature invadopodia) mRNA to mediate its expression, and then promoted cell migration and invasiveness by regulating invadopodia formation 38. The gene discussed is CTTN; the disease is intrahepatic cholangiocarcinoma.