Here, our data revealed that SIRT7 may interact with LAP2α to promote CIN in breast cancer cells, which is supported by our finding that the decreased low transcription levels of chromosomal stability-related genes induced by SIRT7 knockdown were partially compensated for by LAP2α complementation in cancer cells. The gene discussed is SIRT7; the disease is cervical squamous intraepithelial neoplasia.