Based on the extent of inflammatory cell infiltration, severe alcoholic hepatitis was divided into high intrahepatic neutrophils with low CD8+ T cells (NeuhiCD8lo) and NeuloCD8hi subtypes, and the effects of the neutrophil cytosolic factor-1 (NCF-1)/SIRT-1/AMPK axis on lipid metabolism and the NCF-1/p-38 MAPK/miR-223 pathway on alcohol-induced inflammation and fibrosis were further revealed 139. The gene discussed is NCF1; the disease is alcoholic hepatitis.