Adoptive transfer of CD4+ T cells isolated from mice with reduced Ahr ligand binding affinity (Ahrd mice) that were polarized under Tr1 conditions in vitro led to significantly enhanced experimental autoimmune encephalomyelitis (EAE) as compared to mice receiving wild type CD4+ T cells polarized in Tr1 conditions. Here, CD4 is linked to experimental autoimmune encephalomyelitis.