We also found that the frequencies of total CD8+TILs, CD8+TILs in the epithelial cell region, and CD8+TILs in stromal cell region were positively associated with tumor size (P=0.025, P=0.022, P=0.041, respectively, Table 1), and the frequency of CD8+TILs in the epithelial cell region was significantly associated with metastasis stage (M stage) (P=0.021, Table 1), and the frequency of total CD8+TILs could serve as an independent prognostic predictor for GC patients (HR=4.755, 95%CI:1.342-16.85, P=0.016, Table 3). Here, CD8A is linked to neoplasm.