Besides, the GC patients with a higher ratio of CD8+CD226+TILs in total CD8+TILs in the epithelial cell region also favored better OS than those with a lower ratio (HR=0.3256, 95% CI: 0.1940-0.5465, P=0.0013, Figure 3E), and the similar result was found in the stromal cell region (HR=0.5940, 95% CI: 0.3730-0.9459, P=0.0292, Figure 3F). This evidence concerns the gene CD8A and gastric cancer.