In these genes, 12 genes expression were upregulated in ccRCC tissues compared with normal kidney samples in TCGA and GTEx, including UBE2C, PYCARD, TIMP1, CEBPB, MMP9, LGALS1, PECAM1, CSPG4, COL4A2, BNIP3, CCND1, TLR3. This evidence concerns the gene PYCARD and nonpapillary renal cell carcinoma.