In these genes, 12 genes expression were upregulated in ccRCC tissues compared with normal kidney samples in TCGA and GTEx, including UBE2C, PYCARD, TIMP1, CEBPB, MMP9, LGALS1, PECAM1, CSPG4, COL4A2, BNIP3, CCND1, TLR3. Here, COL4A2 is linked to nonpapillary renal cell carcinoma.