In these genes, 12 genes expression were upregulated in ccRCC tissues compared with normal kidney samples in TCGA and GTEx, including UBE2C, PYCARD, TIMP1, CEBPB, MMP9, LGALS1, PECAM1, CSPG4, COL4A2, BNIP3, CCND1, TLR3. The gene discussed is TIMP1; the disease is nonpapillary renal cell carcinoma.