Interestingly, 3 out of the top 8 pathways of the enrichment analysis were predicted to be associated with autoimmunity including allograft rejection (hsa05330), autoimmune thyroid disease (hsa05320), and antigen processing and presentation (hsa04612), through significant negative regulation of HLA-DOA and HLA-DQA1 genes by all selected miRNA (Figure 4A). The gene discussed is HLA-DQA1; the disease is autoimmune thyroid disease.