We then performed RT-qPCR on lung tissues from stable-COPD and AECOPD mice, and the results showed that compared with the control group, the expression levels of IL-1β and CXCL12 mRNA were significantly increased in the stable-COPD group and CEBP-β mRNA in the AECOPD group, while the NFKBIA mRNA The differences in expression levels were not statistically significant. This evidence concerns the gene NFKBIA and chronic obstructive pulmonary disease.