We examined the lung tissues of stable-COPD mice and AECOPD mice by RT-qPCR and showed that compared with the control group, the expression levels of IL-1β and CXCL12 mRNA were significantly increased in the stable-COPD group and CEBP-β mRNA in the AECOPD group, while the NFKBIA mRNA The differences in expression levels were not statistically significant (Figure 9B). The gene discussed is CXCL12; the disease is chronic obstructive pulmonary disease.