Although according to the results of bioinformatic analysis, the 4-OHA treatment decreased the proportion of activated DCs; facilitated the infiltration of naive B cells, resting NK cells, and naïve CD8+ T cells into tumor tissue; and did not activate these three immune cells, qRT-PCR results showed that the expression levels of interferon-signaling genes (e.g., Stat1) and immunosuppressive cytokine genes (e.g., Vegfa) were up- and down-regulated in response to 4-OHA treatments, respectively (Figure 6B). Here, STAT1 is linked to neoplasm.