Furthermore, 4-OHA significantly up-regulated the expression levels of tumor suppressors, such as Lrrc4, Sema3b, Btg1, and Nbl1. Of these tumor suppressors, Btg1 had higher expressed levels in the 4-OHA treatment group than the control group (4-OHA cream 798.8 vs. control 297.8; 4-OHA injection 888.1 vs. 328). Here, SEMA3B is linked to neoplasm.