In vivo experiments have reported that both breast cancer cells and lung cancer cells interact with astrocytes in the central nervous system to improve the expression of survival genes, including B-cell lymphoma-2-like protein 1 (BCL2L1), twist family BHLH transcription factor 1 (TWIST1), and glutathione S-transferase alpha 5 (GSTA5) to obtain drug resistance. Here, TWIST1 is linked to lung cancer.