Additionally, astrocytes which express signal transducer and activator of transcription 3 (STAT3) contribute to BrM by regulating innate and specific immunity as well as establish gap junctions with metastases cells to enhance the growth ability and drug resistance of tumor cells (Chen et al., 2016; Sato et al., 2017; Priego et al., 2018; Kim et al., 2019; Song S. G. et al., 2021; Song Z. et al., 2021). This evidence concerns the gene STAT3 and neoplasm.