MAPT and Parkinson disease: Fiorenzato et al. (2018) found that SDMT scores were significantly lower in Aβ-positive Parkinson’s patients and were significantly associated with increased amyloid deposition in cortical regions (i.e., frontal, posterior cingulate, temporal, parietal, and occipital lobes), which is critical for information processing speed. Aβ can directly induce tau hyperphosphorylation and neurodegeneration (Jin et al., 2011). In our subjects, SDMT was negatively correlated with the serum P-tau181 concentration (r = −0.376, P ≤ 0.001) in pregnant women at an average gestational age of 33.86 ± 7.46 weeks.