And some other biomarkers closely related to obesity and metabolic syndrome components, such as adiponectin, fetuin-A and Peptidase M20 domain containing 1 (PM20D1) measurement of their serum concentrations may be valuable for clinical diagnosis of IR-related metabolic and cardiovascular diseases (5–7). This evidence concerns the gene PM20D1 and obesity due to melanocortin 4 receptor deficiency.