Change in fasting plasma glucose; Change in fasting insulin; HOMA-IR; Decrease of daily insulin dose; BMI; Change in mean blood pressure; Change in heart output; Change in the prevalence of electrocardiogram events; Change in the proportion of hypertension, retinopathy, nephropathy, neuropathy; Change in total cholesterol level, LDL level, HDL level, triglyeride level, ALP, ALT, AST, GGT, glomerular filtration rate, creatinine level, etc. This evidence concerns the gene GPT and Nephropathy.