On the other hand, Wen and coworkers (77) reported that GnRH-conjugated micelles loaded with the antiandrogen C4-2 cells exhibited a higher cellular uptake, promoting increased cell cytotoxicity and apoptosis, and efficient inhibition of prostatic cancer cell proliferation in vitro (approximately 80% of inhibition in C4-2 cells) and tumor growth in vivo (33% compared to only CBDIV17 micelles) after treatment (77). This evidence concerns the gene GNRH1 and prostate cancer.