GnRH-R overexpression has been detected in hormone-dependent cancer tissues, such as breast (101), endometrial (102), ovarian (88, 103, 104), and prostate cancer (105); and also in hormone-independent tissues, such as pancreatic cancer (106, 107), lung cancer (108), melanoma (109), and glioblastoma (110). This evidence concerns the gene GNRHR and familial pancreatic carcinoma.