The mechanism is to inhibit HDAC6 to improve acetylation of microtubulin, promote mitochondrial translocate to the outer end of neurons, provide and maintain necessary energy and nutrition for nerve fibers, stimulate regeneration of intraepidermal nerve fibers (IENFs), restore nerve fiber function, and essentially alleviate and heal peripheral nerve injury (Table 1). Here, HDAC6 is linked to peripheral nerve injury.