However, since PSI regulatory elements conveying evolution perspectives, they can bring new insights into complex regulation mechanisms as shown in the LRP4 example here and previous examples of SLC2A9 regulating urate levels (Takei et al., 2021) and CACNA1C regulating Bipolar Disorder and Schizophrenia (Song et al., 2018). This evidence concerns the gene SLC2A9 and schizophrenia.