Sun and coworkers developed a biodegradable polymeric nanoparticle with multiple components comprising a commercial photosensitizer 5-ALA, a PD-L1 antibody, and upconverting nanoparticles, which was further coated by B1R kinin ligand to assist crossing the blood tumor barrier (Figure 8A) 145. The gene discussed is CD274; the disease is neoplasm.