CD274 and neoplasm: Similarly, Zhou and coworkers employed Tannic acid as ligand to form anti-PD-L1 DNAzyme (DZ) loaded photothermal Mn2+/Fe3+ hybrid metal-phenolic networks (MPNs) nanoplatform (termed DZ@TFM), in which Fe2+ is in situ generated from Fe3+ to trigger ferroptosis for inducing tumor cells ICD, while DNAzyme is activated by Mn2+ to effectively silence PD-L1 (Figure 4H) 95.