YAP1 and nasopharyngeal carcinoma: Another interesting report about the relation of mutualism in NPC is that exosomes released from EBV(+) NPC cells could activate YAP1/FAPα axis pathway to promote CAF-mediated characteristics includes fibrosis/remodeling of the ECM and tumor growth, meanwhile induce an immunosuppressive TME that benefits evading predation from immune system 188.