Strikingly, either rhIL-33 or IL-33 overexpression alone promoted CRC cell proliferation (Figure S6C-D) and suppressed 5-FU-mediated cytotoxicity (Figure 5B-E), which was reversed by ST2 blockade, indicating that the role of IL-33 in promoting CRC cell survival mainly relies on an autocrine manner, but not the endogenous nuclear expression. The gene discussed is IL33; the disease is colorectal carcinoma.