The qPCR analyses showed higher expression levels of IL33, Th1 cytokines (IL2 and IFNG), and Th2 cytokines (IL4 and IL10) in 5-FU-sensitive tumor tissues than in 5-FU-resistant tumor tissues, whereas the expression levels of these cytokines did not significantly differ between normal and peritumor tissues (Figure 1C-G). Here, IL4 is linked to neoplasm.