By analyzing a dataset of anti-PD1 therapy for glioma, we found the expression of AC131097.3, AL590428.1 (also known as CD109-AS1 in GENCODE V41), LINC02447, and LINC01765 were significantly decreased in the patients with immune therapy response (Figure 5E and Figure S8). The gene discussed is CD109; the disease is central nervous system cancer.