One of the main effects of IL-17A in infections and sterile immune responses is to induce the expression of neutrophil attracting CXC-chemokines at the lesion site .14 The finding that we only detected a treatment effect of IL-17A neutralization in large infarcts with cortical involvement raised the question whether the IL-17A—neutrophil axis is predominantly activated in cortical areas. The gene discussed is IL17A; the disease is infection.