Considering that neurodegeneration is closely linked to inflammation in multiple sclerosis, our finding that Nurr1 expression negatively relates to cytotoxic CD8+ inflammation in multiple sclerosis cortex provides support to the possibility that Nurr1’s putative neuroprotective role may be mediated, at least in part, by its influence on T-cell inflammation. The gene discussed is CD8A; the disease is multiple sclerosis.