As previously reported, CD3+/CD8+ lymphocytic inflammation was increased in multiple sclerosis compared with control cases.12 We compared quantitative measures of Nurr1 expression in the extremes of Nurr1 expression (n = 20; Table 1) with lymphocytic (CD3+ and CD8+ T-cell) density in all motor cortical layers (Fig. 4). Here, NR4A2 is linked to multiple sclerosis.