NR4A2 and amyotrophic lateral sclerosis: Functional validation of such a protective role of nuclear Nurr1 expression is corroborated in animal models of amyotrophic lateral sclerosis where nuclear Nurr1 translocation occurred in early disease stages where spinal motor neuronal loss was not severe.15 The conflation of these findings suggests that enhancing Nurr1 expression in the nuclear compartment of motor neurons may provide a putative protective mechanism to halt neurodegeneration and therefore, disability progression in multiple sclerosis.