NR4A2 and multiple sclerosis: In fact, when comparing multiple sclerosis cases showing ‘high’ and ‘low’ Nurr1 expression (Fig. 3C), we found that multiple sclerosis cases with low expression showed decreased neuronal densities compared to high expressing cases (P = 0.033), restricted to supragranular layers (supragranular layers: P = 0.002; infragranular layers: P = 0.37).