NR4A2 and multiple sclerosis: In line with this, it has been shown that Nurr1 upregulates Foxp3 in Treg cells,26 a T-cell subset that is known to suppress CD8+ T cell function, differentiation and expansion.27 Altogether, this suggests that Nurr1 may exert some of its neuroprotective function by modulating the CD8+ T lymphocyte subpopulation in multiple sclerosis cortex.