Nurr1 expression negatively correlated with CD8+ inflammation in multiple sclerosis cases, a finding restricted to infragranular layers (supragranular layers, r = −0.110, P = 0.472; infragranular layers, r = −0.351, P = 0.0014; all layers, r = −0.371, P = 0.012, Fig. 4B). Here, CD8A is linked to multiple sclerosis.