The spectrum of IgE-mediated reactions to wheat allergens ranges from baker’s asthma caused by inhaled allergens [113], primary wheat allergy occurring predominantly in childhood [114, 115], to wheat-dependent exercise-induced anaphylaxis (WDEIA) which is the most common form of food-dependent summation anaphylaxis [115, 116, 117, 118, 119]. This evidence concerns the gene IGHE and anaphylaxis.