Since the myc-Y10F PANX1 mutant has reduced channel activity compared to that of myc-PANX1 and inhibits PANX1 channel activity in a dominant-negative manner, we then wanted to determine if its expression could inhibit NB cell proliferation like what we have observed with PBN- or CBX-treated NB cell lines. Here, PANX1 is linked to neuroblastoma.