CD274 and hepatocellular carcinoma: Bai et al. directly combined PD-1/PD-L1 blockers and cancer vaccines by administering a bio-nanoparticle-based λ phage vaccine—targeting aspartate beta-hydroxylase alone or in combination with PD-1 blockers—to mice bearing syngeneic hepatocellular carcinoma or triple-negative breast cancer tumors.