Given the MCU complex was composed of MCU, MCUb, MCUR1, SMDT1, MICU1, MICU2, and MICU3, and the individual MCU complex members can't effectively predict the prognosis for patients with COAD, a risk score model was constructed based on the expressions of MCU complex members to evaluate the outcomes of patients with COAD. Here, MICU1 is linked to colon adenocarcinoma.