Table 2 shown that five out of the top ten hub genes, namely LCK, ZAP70, CD44, SNAP25, and IL12RB2, were associated with the Alzheimer's pathological pathway (APOE, PSEN1, MAPT), and LCK, ZAP70, CD44, and CD3E were significantly differentially expressed in AD abeta and tau mouse models, respectively. This evidence concerns the gene APOE and Alzheimer disease.