The increased level of RRM2 expression were positively correlated with a higher grade of T stage (P <0.05, Figure 2A), Pathologic stage (P <0.05, Figure 2B), tumor status (P <0.01, Figure 2C), histologic grade (P <0.001, Figure 2D), and AFP levels (P <0.001, Figure 2E). Here, AFP is linked to neoplasm.