Moreover, it has been proven to be positively correlated with the malignant process and poor prognosis of renal cell carcinoma (RCC) (26), pancreatic cancer (PC) (27), bladder cancer (28), leukemia (29), etc. Human tumors have been evaluated concerning SNHG15 expression on a range of tumorigenic characteristics, including cell proliferation, apoptosis, invasion, and metastasis (30). Here, SNHG15 is linked to pachyonychia congenita.