KDM4A-AS1 is aberrantly overexpressed as an oncogene in HCC and promotes HCC growth and metastasis through the miR-411-5p/KPNA2/AKT axis, and high KMD4A-AS1 levels are associated with poor clinical features and poor prognosis (37). This evidence concerns the gene KPNA2 and hepatocellular carcinoma.