The animal model of homocysteinemia with osteoporosis resulted in a higher expression of DNMT1, which then triggered an upsurge in methylation of the OPG promoter, ultimately resulting in reduced OPG transcription and an increase in RANKL expression, thus allowing OC formation to take place and resulting in a decrease in bone density (Behera et al., 2018). Here, TNFSF11 is linked to osteoporosis.