Pan et al. (2018) found that the promoter of the PTGIS gene was detected to be hypermethylated and under-expressed in TGFβ1-activated HSC-T6 and a CCl4-induced liver fibrosis mouse model, whereas enforced expression of PTGIS in vitro and in vivo could counteract the activation of HSCs and even cause apoptosis, thereby alleviating liver fibrosis. The gene discussed is TGFB1; the disease is Hepatic fibrosis.