PTEN and Hepatic fibrosis: PTEN promoter hypermethylation/low expression or deletion has been observed in TGFβ-induced activated HSC-T6 cells in vitro as well as in a CCl4-induced mouse hepatic fibrosis model (Guan et al., 2022), which is mediated by DNMT1 (Zhu et al., 2020; Song H. et al. 2021; Guan et al., 2022).