COL1A1 and Hepatic fibrosis: Additionally, HSCs isolated from MeCP2-knockout mice display decreased expression of myofibroblast marker genes (such as α-smooth muscle actin [SMA] and COL1A1) compared with that in controls, and MeCP2-knockout mice are protected from carbon tetrachloride (CCl4)-induced liver fibrosis (Mann et al., 2010).