SMAD3 and Hepatic fibrosis: As DNMT plays an important role in DNA methylation, DNMT inhibition may block the hypermethylation and downregulate related genes (such as PTGIS, PTEN, and Smad2/Smad3), inhibit the activation and proliferation of HSCs, inhibit the expression of α-SMA and COL1A1 in vitro, and delay liver fibrosis.