Chen et al. (2018) found that enforced expression of SUN2 inhibited the activation of HSCs and exerted antifibrotic effects in TGF-β1-activated HSC-T6 cells. And in CCl4-induced liver fibrosis mice, DNMT3b mediates hypermethylation of the SUN2 gene at CpG sites, leading to a reduction in SUN2 expression, induction of HSC activation, and liver fibrosis. Additionally, Lei et al. (2012) found that overexpression of SUN2 alleviates excessive DNA damage in SUN1/2-knockout mouse embryonic fibroblasts. This evidence concerns the gene TGFB1 and Hepatic fibrosis.