ACTA1 and Hepatic fibrosis: It was confirmed that ALKBH5 expression was significantly lower in human liver fibrosis tissues in mRNA, protein, and immunohistochemical staining compared to controls, and that increased expression of COL1A1 and α-SMA was also consistent with the severity of liver fibrosis detected with Sirius red and Masson trichrome staining (Yang et al., 2022).