Adiponectin is primarily released by the visceral adipose tissue and is the most abundant adipokine, with quantities in the bloodstream inversely associated with obesity, which specifically exerts anti-apoptotic, anti-inflammatory/anti-fibrotic, and insulin-sensitizing effects (Straub and Scherer, 2019). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.