Immunoglobulins (Igs) - including IgA, soluble IgA [SIgA], IgG, IgM, IgE, and IgD – are present in POM, where they resist infant digestive pathways and maintain function in infants (Table 1).111 These functions are especially critical during the early neonatal period because Ig-containing and producing host cells are not present at birth; appearing between 10 days to eight weeks of age depending on Ig.112,113 Thus, young infants rely on innate immune structures (e.g. physical barriers, innate immune cells) and POM antibodies to avoid infection (reviewed in ref.9). The gene discussed is CD79A; the disease is infection.