Alternatively targeting macrophage growth signals, such as anti-colony stimulating factor 1 receptor (CSF-1R) mAbs, can also effectively improve the size of mouse mammary tumor virus (MMTV)-transgenic polyoma middle T oncoprotein (PyMT) spontaneous breast tumors and prolong the survival of mice by eliminating tumor-resident macrophages or M2- type TAMs [117]. The gene discussed is CSF1R; the disease is neoplasm.