In melanoma cells, deficiency in STING signaling leads to reduced immunogenicity of tumor cells and mediates immune escape of tumor cells, while epigenetic reprogramming of the tumor cell-intrinsic STING function re-induces upregulation of MHC-I expression on melanoma cells and enhances the immunogenicity of tumor cells [194, 195]. The gene discussed is STING1; the disease is melanoma.