In addition, targeting the bromodomain and outer end (BET) protein and DNA methyltransferase 3 alpha (DNMT3A), both of which can affect the program of epigeneticization of T cells, restored the proliferative capacity of exhausted T cells, maintained the anti-tumor capacity of T cells under prolonged antigenic stimulation, and enhanced the killing function of CAR-T cells against tumor cells [155, 156]. Here, DNMT3A is linked to neoplasm.