Xiao et al. used single-cell sequencing and found that subsolid node lung cancer had a higher infiltration of CD8+ T cells than solid node lung cancer, while both had a lower infiltration of NK cells, a feature of subsolid nodules that is consistent with the predominant effect of the adaptive immune system and the impaired innate immune system during the equilibrium phase [261]. The gene discussed is CD8A; the disease is lung cancer.