The infiltration of CD8+ T cells was more but the proportions of CD68+ cells (macrophages), α-SMA+ cells (CAFs) and CD31+ cells (endothelial cells) were fewer in human colon cancer tissues with low CYP19A1 expression as compared with high CYP19A1 expression (Fig. 5E). This evidence concerns the gene CYP19A1 and malignant colon neoplasm.