The infiltration of CD8+ T cells was more but the proportions of CD68+ cells (macrophages), α-SMA+ cells (CAFs) and CD31+ cells (endothelial cells) were fewer in human colon cancer tissues with low CYP19A1 expression as compared with high CYP19A1 expression (Fig. 5E). The gene discussed is CYP19A1; the disease is colonic neoplasm.