The antioxidant effect induced by the activation of SIRT1 in T1DM diabetic cardiomyopathy mainly includes the SIRT1/Nrf2 signalling pathway [131], while in T2DM, it includes the Sirt1/forkhead box class O1 (FOXO1) signalling pathway [132]. This evidence concerns the gene SIRT1 and diabetic cardiomyopathy.