STAT3 and infarction: The effect of SGLT2i on this pathway was demonstrated by Lee et al. [108], who found that dapagliflozin induced macrophage polarization to the M2 phenotype and inhibited the M1 phenotype by stimulating signal transducer and activator of transcription 3 (STAT3) signalling in mice with myocardial infarction and attenuated the increase in collagen after infarction.