NLRP1 and Alzheimer disease: In this study, we hypothesized that excessive APP and Aβ generation might activate NLRP1 inflammasome and induce autophagy dysfunction, which engulfs and processes APP to increase Aβ generation in APP/PS1 mice, and knockdown of NLRP1 might improve autophagy dysfunction and decrease Aβ deposition to delay progression of AD.