Moreover, a series of studies confirmed that pyruvate dehydrogenase kinase 1 (PDK1) [91], pyruvate dehydrogenase kinase 4 (PDK4) [92], bromodomain PHD finger transcription factor (BPTF) [93], MYC proto-oncogene (MYC) [94–97] and hypoxia-inducible factor (HIF) [98–100] promoted glycolysis in tumor progression in an m6A-dependent manner. The gene discussed is PDK4; the disease is neoplasm.