IDH1 and central nervous system cancer: Based on the profiles of chromatin status, we identified 4 cell populations in these samples: proliferating IDH-mutant glioma cells (n = 438), non-proliferating IDH-mutant glioma cells (n = 4601), mature oligodendrocytes (n = 306), and microglia/macrophages (n = 464) (Fig. 7A).