IGKV2D-40 and central nervous system cancer: In IDH-mutant/PM gliomas, coordinated hypermethylation in the transcription start site (TSS)/CpG island regions was observed in MO marker (GALC/O1), myelin components (MAG, MBP, MOBP, MOG), and essential regulators of the myelination program (MYRF/C11orf9 [59, 60] and SOX10 [61]) (Fig. 6B and C, Additional file 1: Fig. S18 and Additional file 5: Table S4).