IDH1 and central nervous system cancer: Finally, co-staining with LFB (for myelin structure) and anti-IDH1 R132H antibody in 11 PM gliomas with 1p19q co-deletion and 9 PM gliomas without 1p19q co-deletion confirmed the absence of myelin fibers in tumor regions strongly stained with anti-IDH1 R132H antibody H09 (Fig. 2D and Additional file 1: Fig. S7D).