As APC markers were not enriched in IDH-mutant glioma cells (Fig. 3D and Additional file 1: Fig. S10D), the expression of AC genes in O/C 2 cells would unlikely originate from APC, but more likely from the type-2 astrocyte differentiation potential of the OPC-like malignant cells [66, 67]. Here, IDH1 is linked to central nervous system cancer.